Exercise no. 327 Aztreonam + avibactam (Emblaveo°) in certain serious infections

"Complicated" urinary tract or intra-abdominal infections and hospital-acquired pneumonia are often caused by Gram-negative bacteria, in particular enterobacteria or Pseudomonas aeruginosa. When such an infection is serious, a broad-spectrum antibiotic, such as a "third-generation" cephalosporin or a carbapenem, is an option of choice. The growing use of these drugs is contributing to the increasing incidence of infections with bacteria that produce beta-lactamases, enzymes that reduce the efficacy of many antibiotics. For a serious infection with a beta-lactamase-producing bacterium, a combination of a broad-spectrum antibiotic with a beta-lactamase inhibitor is sometimes useful, such as the third-generation cephalosporin ceftazidime + avibactam or the carbapenem meropenem + vaborbactam.